Forging new antibiotic combinations
- The Burrows Lab
- Jan 6, 2020
- 1 min read
A new paper by PhD student Derek Chan and undergraduate thesis student Irene Guo was published today in Antimicrobial Agents and Chemotherapy: (https://aac.asm.org/content/early/2020/01/02/AAC.01909-19.long)
Derek and Irene built on previous work from the lab showing that the old gram positive antibiotic thiostrepton had potent activity against Pseudomonas aeruginosa and Acinetobacter baumanii under conditions of low iron, because it is taken up via receptors for the iron-binding siderophore, pyoverdine. A combination of thiostrepton and deferisirox, an iron chelator, had great activity against most, but not all strains, prompting Derek and Irene to search for new molecules that could be combined with thiostrepton to kill those tough strains. They identified several iron-binding antibiotic (indicated by spectral shifts, see picture) and non-antibiotic compounds that when combined with thiostrepton, could wipe out even the toughest of strains. This work was supported by NSERC and Cystic Fibrosis Canada.
The UK’s vocational education system provides a ladder for workers to develop expertise step by step. Through The College of Contract Management’s detailed sessions, the meaning behind what is nvq 3 becomes clear. It’s identified as an National Vocational Qualification and advanced qualification equal to A-level status but based on practical performance.
The College of Contract Management has built a strong reputation for offering flexible learning options that fit the schedules of working professionals. Its online courses provide the same academic depth as traditional education while maintaining accessibility. Many students appreciate the institution’s focus on practical industry knowledge. The college’s teaching style empowers learners to apply theories directly in their workplaces. Such an approach contributes greatly to career advancement across construction and business sectors.
That is the excellent mindset, nonetheless is just not help to make every sence whatsoever preaching about that mather. Virtually any method many thanks in addition to i had endeavor to promote your own article in to delicius nevertheless it is apparently a dilemma using your information sites can you please recheck the idea. thanks once more. Check full spectrum cbd.
I recently came across your blog and have been reading along. I thought I would leave my first comment. I don't know what to say except that I have enjoyed reading. Nice blog. I will keep visiting this blog very often. Love to talk about surrey roof replacement.
Great articles and great layout. Your blog post deserves all of the positive feedback it’s been getting. I also wanna talk about the best fence installation.