Forging new antibiotic combinations
- The Burrows Lab
- Jan 6, 2020
- 1 min read
A new paper by PhD student Derek Chan and undergraduate thesis student Irene Guo was published today in Antimicrobial Agents and Chemotherapy: (https://aac.asm.org/content/early/2020/01/02/AAC.01909-19.long)
Derek and Irene built on previous work from the lab showing that the old gram positive antibiotic thiostrepton had potent activity against Pseudomonas aeruginosa and Acinetobacter baumanii under conditions of low iron, because it is taken up via receptors for the iron-binding siderophore, pyoverdine. A combination of thiostrepton and deferisirox, an iron chelator, had great activity against most, but not all strains, prompting Derek and Irene to search for new molecules that could be combined with thiostrepton to kill those tough strains. They identified several iron-binding antibiotic (indicated by spectral shifts, see picture) and non-antibiotic compounds that when combined with thiostrepton, could wipe out even the toughest of strains. This work was supported by NSERC and Cystic Fibrosis Canada.
I read the Burrows Lab post about forging new antibiotic combinations and exploring innovative strategies to combat resistant bacteria and improve treatment outcomes. It’s fascinating to see such scientific progress. For students managing busy schedules, Affordable Accounting Class Help In The USA can provide extra support to stay organized while keeping up with coursework.
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