Lab Members
Lab Members
Lab Members
2025
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Structural conservation and functional role of TfpY-like proteins in type IV pilus assembly. (2025) Qaderi Ikram, Chan Isabelle, Harvey Hanjeong, Burrows Lori L. J. Bacterio. 2025 Feb 207(2) PMID:39817748 doi: 10.1128/jb.00343-24
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Perturbation of Pseudomonas aeruginosa peptidoglycan recycling by anti-folates and design of a dual-action inhibitor. (2025) Yaeger Luke N, Synchantha David, Luong Princeton, Shekarriz Shahrokh, Goncalves Océane, Dobrin Annamaria, Ranieri Michael R, Lamers Ryan P, Harvey Hanjeong, diCenzo George C, Surette Michael, Côté Jean-Philippe, Magolan Jakob, Burrows Lori L. mBio. 2025 Mar 12;16(3) PMID:39878530 doi: 10.1128/mbio.02984-24
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Hyperpiliation, not loss of pilus retraction, reduces Pseudomonas aeruginosa pathogenicity. (2025) Kilmury Sara LN, Graham Katherine J, Lamers Ryan P, MacNeil Lesley T, Burrows Lori L. Microbiol Spectr. 2025 Apr; 13(4) PMID:39998244 doi: 10.1128/spectrum.02558-24
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Twitching motility suppressors reveal a role for FimX in type IV pilus extension dynamics. (2025) Roberge Nathan, Yuen Nathan, Harvey Hanjeong, Ellison Taylor J, Ellison Courtney K, Burrows Lori L. PLoS Genetics. 2025 Oct 13;21(10) PMID:41082515 doi: 10.1371/journal.pgen.1011802.
2024
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It's uncomplicated: Prevention of urinary tract infections in an era of increasing antibiotic resistance. (2024) Burrows Lori L. PLOS Pathology. 2024 Feb1; 20(2) PMID: 38300901
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A genetic screen identifies a role for oprF in Pseudomonas aeruginosa biofilm stimulation by subinhibitory antibiotics. (2024) Yaeger Luke N., Ranieri Michael RM, Chee Jessica, Karabelas-Pittman Sawyer, Rudolph Madeleine, Giovannoni Alessio M., Harvey Hanjeong, Burrows Lori L. NPJ Biofilms Microbiomes, 2024 March 23;10(1):30 PMID:38521769
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The effects of chlorhexidine, povidone-iodine and vancomycin on growth and biofilms of pathogens that cause prosthetic joint infections: an in-vitro model. (2024) Coles Victoria E, Puri L, Bhandari M, Wood TJ, Burrows Lori L. Journal of Hospital Infection. 2024 Sep: 151:99-108 PMID: 38992843
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High-Throughput Discovery of Synthetic Siderophores for Trojan Horse Antibiotics. (2024) Weber Brent S, Ritchie Nikki E, Hilker Simon, Chan Derek CK, Peukert Carsten, Deisinger Julia P, Årdal Christine, Burrows Lori L, Brönstrup Mark, Magolan Jakob, Raivio Tracy L, Brown Eric D. ACS Infectious Disease. 2024 Nov 8;10 (11):3821-3841 PMID: 39438291
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Building permits-control of type IV pilus assembly by PilB and its cofactors. (2024) Roberge Nathan A, Burrows Lori L. J. Bacteriology. 2024 Dec 19; 206(12) PMID: 39508682
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Cryo-EM characterization of the anydromuropeptide permease AmpG central to bacterial fitness and β-lactam antibiotic resistance. (2024) Sverak HE, Yaeger Luke N, Worrall LJ, Vacariu CM, Glenwright AJ, Vuckovic M, Al Azawi Zayni-Dean, Lamers Ryan P, Marko Victoria A, Skorupski C, Soni AS, Tanner ME, Burrows Lori L., Strynadja NCJ. Nature Communications. 2024 Nov 16;15(1):9936 PMID: 39548104
2023
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Central metabolism is a key player in E. coli biofilm stimulation by sub-MIC antibiotics. (2023) Yaeger Luke N, French Shawn, Brown Eric D, Côté Jean Philippe, Burrows Lori L. PLOS genetics. 2023 Nov 2;19(11) PMID: 37917668
2021
2020
2019
2018
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Diversity and Evolution of Myxobacterial Type IV Pilus Systems. (2018). Sharma Gaurav, Burrows Lori L, Singer Mitchell. Frontiers in Microbiology. PubMed: PMID:30072980
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Mechanisms of biofilm stimulation by subinhibitory concentrations of antimicrobials. (2018). Ranieri Michael R, Whitchurch Cynthia B, Burrows Lori L. Current opinion in microbiology. PubMed: PMID:30053750
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The Pseudomonas aeruginosa PilSR Two-Component System Regulates Both Twitching and Swimming Motilities. (2018). Kilmury Sara L N, Burrows Lori L. mBio. PubMed: PMID:30042200
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Pseudomonas aeruginosa type IV minor pilins and PilY1 regulate virulence by modulating FimS-AlgR activity. (2018). Marko Victoria A, Kilmury Sara L N, MacNeil Lesley T, Burrows Lori L. PLoS Pathogens. PubMed: PMID:29775484
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The Therapeutic Pipeline for Pseudomonas aeruginosa Infections. (2018). Burrows Lori L. ACS Infectious Diseases. PubMed: PMID:29771109
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Conserved, unstructured regions in Pseudomonas aeruginosa PilO are important for type IVa pilus function. (2018).
Leighton T L, Mok M C, Junop M S, Howell P L, Burrows L L. Scientific Reports. PubMed: PMID:29422606
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A Highly Dynamic Loop of the Pseudomonas aeruginosa PA14 Type IV Pilin Is Essential for Pilus Assembly. (2018).
Nguyen Ylan, Boulton Stephen, McNicholl E Tyler, Akimoto Madoka, Harvey Hanjeong, Aidoo Francisca, Melacini Giuseppe, Burrows Lori L. ACS infectious diseases. PubMed: PMID:29342354
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Pseudomonas aeruginosa defends against phages through type IV pilus glycosylation. (2018). Harvey Hanjeong, Bondy-Denomy Joseph, Marquis Hélène, Sztanko Kristina M, Davidson Alan R, Burrows Lori L. Nature Microbiology. PubMed: PMID:29133883
2017
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Cyclic AMP-Independent Control of Twitching Motility in Pseudomonas aeruginosa. (2017). Buensuceso Ryan N C, Daniel-Ivad Martin, Kilmury Sara L N, Leighton Tiffany L, Harvey Hanjeong, Howell P Lynne, Burrows Lori L. Journal of bacteriology. PubMed: PMID:28583947
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The molecular mechanism of the type IVa pilus motors. (2017). McCallum Matthew, Tammam Stephanie, Khan Ahmad, Burrows Lori L, Howell P Lynne. Nature communications. PubMed: PMID:28474682
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The Type IVa Pilus Machinery Is Recruited to Sites of Future Cell Division. (2017). Carter Tyson, Buensuceso Ryan N C, Tammam Stephanie, Lamers Ryan P, Harvey Hanjeong, Howell P Lynne, Burrows Lori L. mBio. PubMed: PMID:28143978
2016
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Structure of the Pseudomonas aeruginosa Type IVa Pilus Secretin at 7.4 Å. (2016). Koo Jason, Lamers Ryan P, Rubinstein John L, Burrows Lori L, Howell P Lynne. Structure (London, England : 1993). PubMed: PMID:27705815
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The Conserved Tetratricopeptide Repeat-Containing C-Terminal Domain of Pseudomonas aeruginosa FimV Is Required for Its Cyclic AMP-Dependent and -Independent Functions. (2016). Buensuceso Ryan N C, Nguyen Ylan, Zhang Kun, Daniel-Ivad Martin et al. Journal of bacteriology. PubMed: PMID:27297880
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Pseudomonas aeruginosa: targeting cell-wall metabolism for new antibacterial discovery and development. (2016).
Lamers Ryan P, Burrows Lori L. Future medicinal chemistry. PubMed: PMID:27228070
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Type IV pilins regulate their own expression via direct intramembrane interactions with the sensor kinase PilS. (2016). Kilmury Sara L N, Burrows Lori L. Proceedings of the National Academy of Sciences of the United States of America. PubMed: PMID:27162347
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PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM. (2016). McCallum Matthew, Tammam Stephanie, Little Dustin J, Robinson Howard et al. The Journal of biological chemistry. PubMed: PMID:27022027
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Loss of membrane-bound lytic transglycosylases increases outer membrane permeability and β-lactam sensitivity in Pseudomonas aeruginosa. (2016). Lamers Ryan P, Nguyen Uyen T, Nguyen Ylan, Buensuceso Ryan N C, Burrows Lori L. MicrobiologyOpen. PubMed: PMID:26374494
2015-2010
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Structural and functional studies of the Pseudomonas aeruginosa minor pilin, PilE. (2015). Nguyen Ylan, Harvey Hanjeong, Sugiman-Marangos Seiji, Bell Stephanie D, Buensuceso Ryan N C, Junop Murray S, Burrows Lori L. The Journal of biological chemistry. PubMed: PMID:26359492
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Nanoscale Pulling of Type IV Pili Reveals Their Flexibility and Adhesion to Surfaces over Extended Lengths of the Pili. (2015). Lu Shun, Giuliani Maximiliano, Harvey Hanjeong, Burrows Lori L, Wickham Robert A, Dutcher John R. Biophysical journal. PubMed: PMID:26083926
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Novel Role for PilNO in Type IV Pilus Retraction Revealed by Alignment Subcomplex Mutations. (2015). Leighton Tiffany L, Dayalani Neha, Sampaleanu Liliana M, Howell P Lynne, Burrows Lori L. Journal of bacteriology. PubMed: PMID:25917913
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Biogenesis of Pseudomonas aeruginosa type IV pili and regulation of their function. (2015). Leighton Tiffany L, Buensuceso Ryan N C, Howell P Lynne, Burrows Lori L. Environmental microbiology. PubMed: PMID:25808785
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Pseudomonas aeruginosa minor pilins prime type IVa pilus assembly and promote surface display of the PilY1 adhesin. (2015). Nguyen Ylan, Sugiman-Marangos Seiji, Harvey Hanjeong, Bell Stephanie D, Charlton Carmen L, Junop Murray S, Burrows Lori L. The Journal of biological chemistry. PubMed: PMID:25389296
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Changes to its peptidoglycan-remodeling enzyme repertoire modulate β-lactam resistance in Pseudomonas aeruginosa. (2013). Cavallari Joseph F, Lamers Ryan P, Scheurwater Edie M, Matos Andrea L, Burrows Lori L. Antimicrobial agents and chemotherapy. PubMed: PMID:23612194
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Functional mapping of PilF and PilQ in the Pseudomonas aeruginosa type IV pilus system. (2013). Koo Jason, Tang Tim, Harvey Hanjeong, Tammam Stephanie, Sampaleanu Liliana, Burrows Lori L, Howell P Lynne. Biochemistry. PubMed: PMID:23547883
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The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria. (2013). Lamers Ryan P, Cavallari Joseph F, Burrows Lori L. PloS one. PubMed: PMID:23544160
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PilMNOPQ from the Pseudomonas aeruginosa type IV pilus system form a transenvelope protein interaction network that interacts with PilA. (2013). Tammam Stephanie, Sampaleanu Liliana M, Koo Jason, Manoharan Kumararaaj, Daubaras Mark, Burrows Lori L, Howell P Lynne. Journal of bacteriology. PubMed: PMID:23457250
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The platform protein is essential for type IV pilus biogenesis. (2013). Takhar Herlinder K, Kemp Kevin, Kim Melissa, Howell P Lynne, Burrows Lori L. The Journal of biological chemistry. PubMed: PMID:23413032
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Type IV pilin proteins: versatile molecular modules. (2012). Giltner Carmen L, Nguyen Ylan, Burrows Lori L. Microbiology and molecular biology reviews: MMBR. PubMed: PMID:23204365
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Pseudomonas aeruginosa twitching motility: type IV pili in action. (2012). Burrows Lori L. Annual review of microbiology. PubMed: PMID:22746331
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Decoding the roles of pilotins and accessory proteins in secretin escort services. (2012). Koo Jason, Burrows Lori L, Howell P Lynne. FEMS microbiology letters. PubMed: PMID:22098485
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Characterization of the PilN, PilO and PilP type IVa pilus subcomplex. (2011). Tammam S, Sampaleanu L M, Koo J, Sundaram P et al. Molecular microbiology. PubMed: PMID:22053789
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Palmitoyl-DL-carnitine is a multitarget inhibitor of Pseudomonas aeruginosa biofilm development. (2011). Wenderska Iwona B, Chong Matthew, McNulty James, Wright Gerard D, Burrows Lori L. Chembiochem: a European journal of chemical biology. PubMed: PMID:22045628
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Pseudomonas aeruginosa D-arabinofuranose biosynthetic pathway and its role in type IV pilus assembly. (2011). Harvey Hanjeong, Kus Julianne V, Tessier Luc, Kelly John, Burrows Lori L. The Journal of biological chemistry. PubMed: PMID:21676874
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Maintaining network security: how macromolecular structures cross the peptidoglycan layer. (2011). Scheurwater Edie M, Burrows Lori L. FEMS microbiology letters. PubMed: PMID:21276045
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Pseudomonas aeruginosa minor pilins are incorporated into type IV pili. (2010). Giltner Carmen L, Habash Marc, Burrows Lori L. Journal of molecular biology. PubMed: PMID:20338182
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AlgK is a TPR-containing protein and the periplasmic component of a novel exopolysaccharide secretin. (2010). Keiski Carrie-Lynn, Harwich Michael, Jain Sumita, Neculai Ana Mirela et al. Structure (London, England: 1993). PubMed: PMID:20159471
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Structural characterization of novel Pseudomonas aeruginosa type IV pilins. (2010). Nguyen Ylan, Jackson Sean G, Aidoo Francisca, Junop Murray, Burrows Lori L. Journal of molecular biology. PubMed: PMID:19895819
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Periplasmic domains of Pseudomonas aeruginosa PilN and PilO form a stable heterodimeric complex. (2009). Sampaleanu L M, Bonanno J B, Ayers M, Koo J et al. Journal of molecular biology. PubMed: PMID:19857646
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PilM/N/O/P proteins form an inner membrane complex that affects the stability of the Pseudomonas aeruginosa type IV pilus secretin. (2009). Ayers M, Sampaleanu L M, Tammam S, Koo J, Harvey H, Howell P L, Burrows L L. Journal of molecular biology. PubMed: PMID:19857645
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Single-residue changes in the C-terminal disulfide-bonded loop of the Pseudomonas aeruginosa type IV pilin influence pilus assembly and twitching motility. (2009). Harvey Hanjeong, Habash Marc, Aidoo Francisca, Burrows Lori L. Journal of bacteriology. PubMed: PMID:19717595
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Hypertonic saline resuscitation from hemorrhagic shock does not impair the neutrophil response to intraabdominal infection. (2008). Papia Giuseppe, Burrows Lori L, Sinnadurai Selva, Marshall John C, Tawadros Patrick S, Kapus Andras, Rotstein Ori D. Surgery. PubMed: PMID:19081025
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Modification of Pseudomonas aeruginosa Pa5196 type IV Pilins at multiple sites with D-Araf by a novel GT-C family Arabinosyltransferase, TfpW. (2008). Kus Julianne V, Kelly John, Tessier Luc, Harvey Hanjeong, Cvitkovitch Dennis G, Burrows Lori L. Journal of bacteriology. PubMed: PMID:18805982
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Novel proteins that modulate type IV pilus retraction dynamics in Pseudomonas aeruginosa. (2008). Asikyan Miranda L, Kus Julianne V, Burrows Lori L. Journal of bacteriology. PubMed: PMID:18776014