Lab Members
Lab Members
Lab Members
2021
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Thiopeptides: antibiotics with unique chemical structures and diverse biological activities. (2021) Chan DCK, Burrows LL. J Antibiot. 2021 Mar;74(3):161-175. doi: 10.1038/s41429-020-00387-x. PMID: 33349675.
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How to kill Pseudomonas- emerging therapies for a challenging pathogen (2021) Yaeger LN, Coles VE, Chan DCK, Burrows LL. Ann N Y Acad Sci. 2021 Jul;1496(1):59-81. doi: 10.1111/nyas.14596. PMID: 33830543.
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Thiocillin and micrococcin exploit the ferrioxamine receptor of Pseudomonas aeruginosa for uptake. (2021) Chan DCK, Burrows LL. J Antimicrob Chemother. 2021 Jul 15;76(8):2029-2039. doi: 10.1093/jac/dkab124. PMID: 33907816.
2020
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Forging new antibiotic combinations under iron-limiting conditions. (2020) Chan DCK, Guo I, Burrows LL. Antimicrob Agents Chemother. 2020 Jan 6. pii: AAC.01909-19. doi: 10.1128/AAC.01909-19. PMID:31907180
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Heads or tails for type V pilus assembly. (2020) Burrows LL. Nat Microbiol. 2020 Jun;5(6):782-784. doi: 10.1038/s41564-020-0732-y. PMID: 32467624.
2019
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Thiostrepton Hijacks Pyoverdine Receptors To Inhibit Growth of Pseudomonas aeruginosa. (2019) Ranieri MRM, Chan DCK, Yaeger LN, Rudolph M, Karabelas-Pittman S, Abdo H, Chee J, Harvey H, Nguyen U, Burrows LL. Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00472-19. doi: 10.1128/AAC.00472-19. PMID:31262758
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The Dynamic Structures of the Type IV Pilus. (2019). Mccallum Matthew, Burrows Lori L, Howell P Lynne. Microbiology Spectrum 7 (2). PMID: 30825300
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Multiple conformations facilitate PilT function in the type IV pilus. (2019). McCallum Matthew, Benlekbir Samir, Nguyen Sheryl, Tammam Stephanie, Rubinstein John L, Burrows Lori L, Howell Lynne P. bioRxiv. doi: https://doi.org/10.1101/672212
2018
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Diversity and Evolution of Myxobacterial Type IV Pilus Systems. (2018). Sharma Gaurav, Burrows Lori L, Singer Mitchell. Frontiers in Microbiology. PubMed: PMID:30072980
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Mechanisms of biofilm stimulation by subinhibitory concentrations of antimicrobials. (2018). Ranieri Michael R, Whitchurch Cynthia B, Burrows Lori L. Current opinion in microbiology. PubMed: PMID:30053750
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The Pseudomonas aeruginosa PilSR Two-Component System Regulates Both Twitching and Swimming Motilities. (2018). Kilmury Sara L N, Burrows Lori L. mBio. PubMed: PMID:30042200
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Pseudomonas aeruginosa type IV minor pilins and PilY1 regulate virulence by modulating FimS-AlgR activity. (2018). Marko Victoria A, Kilmury Sara L N, MacNeil Lesley T, Burrows Lori L. PLoS Pathogens. PubMed: PMID:29775484
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The Therapeutic Pipeline for Pseudomonas aeruginosa Infections. (2018). Burrows Lori L. ACS Infectious Diseases. PubMed: PMID:29771109
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Conserved, unstructured regions in Pseudomonas aeruginosa PilO are important for type IVa pilus function. (2018).
Leighton T L, Mok M C, Junop M S, Howell P L, Burrows L L. Scientific Reports. PubMed: PMID:29422606
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A Highly Dynamic Loop of the Pseudomonas aeruginosa PA14 Type IV Pilin Is Essential for Pilus Assembly. (2018).
Nguyen Ylan, Boulton Stephen, McNicholl E Tyler, Akimoto Madoka, Harvey Hanjeong, Aidoo Francisca, Melacini Giuseppe, Burrows Lori L. ACS infectious diseases. PubMed: PMID:29342354
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Pseudomonas aeruginosa defends against phages through type IV pilus glycosylation. (2018). Harvey Hanjeong, Bondy-Denomy Joseph, Marquis Hélène, Sztanko Kristina M, Davidson Alan R, Burrows Lori L. Nature Microbiology. PubMed: PMID:29133883
2017
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Cyclic AMP-Independent Control of Twitching Motility in Pseudomonas aeruginosa. (2017). Buensuceso Ryan N C, Daniel-Ivad Martin, Kilmury Sara L N, Leighton Tiffany L, Harvey Hanjeong, Howell P Lynne, Burrows Lori L. Journal of bacteriology. PubMed: PMID:28583947
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The molecular mechanism of the type IVa pilus motors. (2017). McCallum Matthew, Tammam Stephanie, Khan Ahmad, Burrows Lori L, Howell P Lynne. Nature communications. PubMed: PMID:28474682
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The Type IVa Pilus Machinery Is Recruited to Sites of Future Cell Division. (2017). Carter Tyson, Buensuceso Ryan N C, Tammam Stephanie, Lamers Ryan P, Harvey Hanjeong, Howell P Lynne, Burrows Lori L. mBio. PubMed: PMID:28143978
2016
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Structure of the Pseudomonas aeruginosa Type IVa Pilus Secretin at 7.4 Å. (2016). Koo Jason, Lamers Ryan P, Rubinstein John L, Burrows Lori L, Howell P Lynne. Structure (London, England : 1993). PubMed: PMID:27705815
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The Conserved Tetratricopeptide Repeat-Containing C-Terminal Domain of Pseudomonas aeruginosa FimV Is Required for Its Cyclic AMP-Dependent and -Independent Functions. (2016). Buensuceso Ryan N C, Nguyen Ylan, Zhang Kun, Daniel-Ivad Martin et al. Journal of bacteriology. PubMed: PMID:27297880
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Pseudomonas aeruginosa: targeting cell-wall metabolism for new antibacterial discovery and development. (2016).
Lamers Ryan P, Burrows Lori L. Future medicinal chemistry. PubMed: PMID:27228070
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Type IV pilins regulate their own expression via direct intramembrane interactions with the sensor kinase PilS. (2016). Kilmury Sara L N, Burrows Lori L. Proceedings of the National Academy of Sciences of the United States of America. PubMed: PMID:27162347
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PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM. (2016). McCallum Matthew, Tammam Stephanie, Little Dustin J, Robinson Howard et al. The Journal of biological chemistry. PubMed: PMID:27022027
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Loss of membrane-bound lytic transglycosylases increases outer membrane permeability and β-lactam sensitivity in Pseudomonas aeruginosa. (2016). Lamers Ryan P, Nguyen Uyen T, Nguyen Ylan, Buensuceso Ryan N C, Burrows Lori L. MicrobiologyOpen. PubMed: PMID:26374494
2015
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Structural and functional studies of the Pseudomonas aeruginosa minor pilin, PilE. (2015). Nguyen Ylan, Harvey Hanjeong, Sugiman-Marangos Seiji, Bell Stephanie D, Buensuceso Ryan N C, Junop Murray S, Burrows Lori L. The Journal of biological chemistry. PubMed: PMID:26359492
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Nanoscale Pulling of Type IV Pili Reveals Their Flexibility and Adhesion to Surfaces over Extended Lengths of the Pili. (2015). Lu Shun, Giuliani Maximiliano, Harvey Hanjeong, Burrows Lori L, Wickham Robert A, Dutcher John R. Biophysical journal. PubMed: PMID:26083926
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Novel Role for PilNO in Type IV Pilus Retraction Revealed by Alignment Subcomplex Mutations. (2015). Leighton Tiffany L, Dayalani Neha, Sampaleanu Liliana M, Howell P Lynne, Burrows Lori L. Journal of bacteriology. PubMed: PMID:25917913
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Biogenesis of Pseudomonas aeruginosa type IV pili and regulation of their function. (2015). Leighton Tiffany L, Buensuceso Ryan N C, Howell P Lynne, Burrows Lori L. Environmental microbiology. PubMed: PMID:25808785
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Pseudomonas aeruginosa minor pilins prime type IVa pilus assembly and promote surface display of the PilY1 adhesin. (2015). Nguyen Ylan, Sugiman-Marangos Seiji, Harvey Hanjeong, Bell Stephanie D, Charlton Carmen L, Junop Murray S, Burrows Lori L. The Journal of biological chemistry. PubMed: PMID:25389296
2014
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Role of PBPD1 in stimulation of Listeria monocytogenes biofilm formation by subminimal inhibitory β-lactam concentrations. (2014). Nguyen Uyen T, Harvey Hanjeong, Hogan Andrew J, Afonso Alexandria C F, Wright Gerard D, Burrows Lori L. Antimicrobial agents and chemotherapy. PubMed: PMID:25136010
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DNase I and proteinase K impair Listeria monocytogenes biofilm formation and induce dispersal of pre-existing biofilms. (2014). Nguyen Uyen T, Burrows Lori L. International journal of food microbiology. PubMed: PMID:25043896
2013
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Changes to its peptidoglycan-remodeling enzyme repertoire modulate β-lactam resistance in Pseudomonas aeruginosa. (2013). Cavallari Joseph F, Lamers Ryan P, Scheurwater Edie M, Matos Andrea L, Burrows Lori L. Antimicrobial agents and chemotherapy. PubMed: PMID:23612194
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Functional mapping of PilF and PilQ in the Pseudomonas aeruginosa type IV pilus system. (2013). Koo Jason, Tang Tim, Harvey Hanjeong, Tammam Stephanie, Sampaleanu Liliana, Burrows Lori L, Howell P Lynne. Biochemistry. PubMed: PMID:23547883
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The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria. (2013). Lamers Ryan P, Cavallari Joseph F, Burrows Lori L. PloS one. PubMed: PMID:23544160
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PilMNOPQ from the Pseudomonas aeruginosa type IV pilus system form a transenvelope protein interaction network that interacts with PilA. (2013). Tammam Stephanie, Sampaleanu Liliana M, Koo Jason, Manoharan Kumararaaj, Daubaras Mark, Burrows Lori L, Howell P Lynne. Journal of bacteriology. PubMed: PMID:23457250
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The platform protein is essential for type IV pilus biogenesis. (2013). Takhar Herlinder K, Kemp Kevin, Kim Melissa, Howell P Lynne, Burrows Lori L. The Journal of biological chemistry. PubMed: PMID:23413032
2012-2010
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Type IV pilin proteins: versatile molecular modules. (2012). Giltner Carmen L, Nguyen Ylan, Burrows Lori L. Microbiology and molecular biology reviews: MMBR. PubMed: PMID:23204365
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Pseudomonas aeruginosa twitching motility: type IV pili in action. (2012). Burrows Lori L. Annual review of microbiology. PubMed: PMID:22746331
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Decoding the roles of pilotins and accessory proteins in secretin escort services. (2012). Koo Jason, Burrows Lori L, Howell P Lynne. FEMS microbiology letters. PubMed: PMID:22098485
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Characterization of the PilN, PilO and PilP type IVa pilus subcomplex. (2011). Tammam S, Sampaleanu L M, Koo J, Sundaram P et al. Molecular microbiology. PubMed: PMID:22053789
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Palmitoyl-DL-carnitine is a multitarget inhibitor of Pseudomonas aeruginosa biofilm development. (2011). Wenderska Iwona B, Chong Matthew, McNulty James, Wright Gerard D, Burrows Lori L. Chembiochem: a European journal of chemical biology. PubMed: PMID:22045628
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Pseudomonas aeruginosa D-arabinofuranose biosynthetic pathway and its role in type IV pilus assembly. (2011). Harvey Hanjeong, Kus Julianne V, Tessier Luc, Kelly John, Burrows Lori L. The Journal of biological chemistry. PubMed: PMID:21676874
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Maintaining network security: how macromolecular structures cross the peptidoglycan layer. (2011). Scheurwater Edie M, Burrows Lori L. FEMS microbiology letters. PubMed: PMID:21276045
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Pseudomonas aeruginosa minor pilins are incorporated into type IV pili. (2010). Giltner Carmen L, Habash Marc, Burrows Lori L. Journal of molecular biology. PubMed: PMID:20338182
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AlgK is a TPR-containing protein and the periplasmic component of a novel exopolysaccharide secretin. (2010). Keiski Carrie-Lynn, Harwich Michael, Jain Sumita, Neculai Ana Mirela et al. Structure (London, England: 1993). PubMed: PMID:20159471
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Structural characterization of novel Pseudomonas aeruginosa type IV pilins. (2010). Nguyen Ylan, Jackson Sean G, Aidoo Francisca, Junop Murray, Burrows Lori L. Journal of molecular biology. PubMed: PMID:19895819
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Periplasmic domains of Pseudomonas aeruginosa PilN and PilO form a stable heterodimeric complex. (2009). Sampaleanu L M, Bonanno J B, Ayers M, Koo J et al. Journal of molecular biology. PubMed: PMID:19857646
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PilM/N/O/P proteins form an inner membrane complex that affects the stability of the Pseudomonas aeruginosa type IV pilus secretin. (2009). Ayers M, Sampaleanu L M, Tammam S, Koo J, Harvey H, Howell P L, Burrows L L. Journal of molecular biology. PubMed: PMID:19857645
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Single-residue changes in the C-terminal disulfide-bonded loop of the Pseudomonas aeruginosa type IV pilin influence pilus assembly and twitching motility. (2009). Harvey Hanjeong, Habash Marc, Aidoo Francisca, Burrows Lori L. Journal of bacteriology. PubMed: PMID:19717595
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Hypertonic saline resuscitation from hemorrhagic shock does not impair the neutrophil response to intraabdominal infection. (2008). Papia Giuseppe, Burrows Lori L, Sinnadurai Selva, Marshall John C, Tawadros Patrick S, Kapus Andras, Rotstein Ori D. Surgery. PubMed: PMID:19081025
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Modification of Pseudomonas aeruginosa Pa5196 type IV Pilins at multiple sites with D-Araf by a novel GT-C family Arabinosyltransferase, TfpW. (2008). Kus Julianne V, Kelly John, Tessier Luc, Harvey Hanjeong, Cvitkovitch Dennis G, Burrows Lori L. Journal of bacteriology. PubMed: PMID:18805982
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Novel proteins that modulate type IV pilus retraction dynamics in Pseudomonas aeruginosa. (2008). Asikyan Miranda L, Kus Julianne V, Burrows Lori L. Journal of bacteriology. PubMed: PMID:18776014