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New FimV paper published

  • Writer: The Burrows Lab
    The Burrows Lab
  • Jun 13, 2016
  • 1 min read

Updated: Nov 28, 2019



FimV is one of the most challenging proteins we’ve worked on for many reasons, but it is really important for twitching motility in P. aeruginosa. In a very collaborative project involving microbiology, biochemistry, bioinformatics, and structural biology, PhD candidate Ryan Buensuceso and friends showed that a highly conserved segment of the protein at its C-terminus interacts with FimL, an activator of the enzyme that makes cAMP – a small molecule critical to expression of virulence factors. The same region is also responsible for cAMP-independent functions of FimV, making it a good place to target inhibitors. The crystal structure of this region will help in the design of such drugs. Well done everyone!

 
 
 

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The Burrows Lab

MDCL 2310
1280 Main Street West
Hamilton, ON Canada L8S 4K1
Tel: 905-525-9140 x26583
Email: lori.burrows@mcmaster.ca

  • Dr. Lori Burrrows
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